Our new data released today focuses on the top anti-chemical antibodies and their targets.
The majority of antibodies are raised against proteins – but some are raised against other molecules, which we term anti-chemical antibodies.
CiteAb Product Manager Rhys Williams said: “To produce this dataset we looked at 2700 citations for antibodies raised against chemicals, plotting the product codes against the count of pubmed IDs for each product. We used this analysis to identify the top ten antibodies raised against chemicals.
“Interesting points to note include the fact that the top ten antibodies represent 50 per cent of the citation share for chemical antibodies, come from 7 different suppliers, and have 5 unique targets.”
Our data shows that the most used chemical target of those chemical antibodies featured in our top ten is bromodeoxyuridine (BRDU). Rhys adds: “This really comes as no surprise given the extensive use of BRDU as a cell cycle marker. As a result we see BRDU as the target of 50 per cent of the antibodies we have featured in our top 10, with a strong hold of the first and second most cited chemical antibodies.”
The third most cited chemical antibody is anti-gamma-Aminobutyric acid (GABA). GABA is a major inhibitory neurotransmitter and acts at inhibitory synapses in the mammalian central nervous system, essentially reducing the activity of the neuron to which it binds. These antibodies provide an important means to study the modulation, regulation and overall function of GABA.
In fourth place is another BRDU specific antibody, however fifth place is occupied by an anti-Nitrotyrosine antibody. Nitrotyrosine has been shown to be an indicator of cell damage, inflammation, and the production of Nitric oxide (NO). Anti-Nitrotyrosine antibodies have therefore been used as a marker for cell damage caused by NO.
We are giving away the data for the top ten most cited chemical antibodies and their chemical targets for free – all you need to do is sign up below and we’ll email you the dataset. If you are interested in our full and detailed data set on chemical antibodies please do get in touch and we’ll be able to discuss options with you.
– Andrew and the CiteAb team
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